Comparison of Live Attenuated Cold-Adapted and Avian-Human Influenza A/Bethesda/85 (H3N2) Reassortant Virus Vaccines in Infants and Children
Identifieur interne : 002099 ( Main/Exploration ); précédent : 002098; suivant : 002100Comparison of Live Attenuated Cold-Adapted and Avian-Human Influenza A/Bethesda/85 (H3N2) Reassortant Virus Vaccines in Infants and Children
Auteurs : Mark C. Steinhoff [États-Unis] ; Neal A. Halsey [États-Unis] ; Modena H. Wilson [États-Unis] ; Barbara A. Burns [États-Unis] ; Roberta K. Samorodin [États-Unis] ; Louis F. Fries [États-Unis] ; Brian R. Murphy [États-Unis] ; Mary Lou Clements [États-Unis]Source :
- Journal of Infectious Diseases [ 0022-1899 ] ; 1990.
Abstract
Randomized, placebo-controlled studies with 103–10' 50% tissue-culture infectious dose (TCID50) of avian-human (ah) and cold-adapted (ca) influenza A/Bethesda/85 (H3N2) reassortant viruses were completed in 106 seronegative young children 6–48 months of age. Although the reassortants differed in six of eight RNA segments, they exhibited similar properties in level of attenuation, infectivity, immunogenicity, and efficacy. The 50% human infectious dose was 104.6 TCID50 for ah and 104.4 for ca vaccines. Both reassortants were satisfactorily attenuated with restricted replication and were no more reactogenic than placebo. The mean peak titer of virus shed was 101.5 (ah) to 102.0 (ca) TCID50/ml, and each of 37 isolates tested retained their characteristic vaccine phenotypes. Infection with ah or ca virus conferred immunity to experimental challenge with homologous virus. These findings indicate that both ah and ca influenza A/Bethesda/85 (H3N2) reassortants should be suitable vaccine candidates for use in healthy infants and young children.
Url:
DOI: 10.1093/infdis/162.2.394
Affiliations:
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Samorodin</name></author><author><name sortKey="Fries, Louis F" sort="Fries, Louis F" uniqKey="Fries L" first="Louis F." last="Fries">Louis F. Fries</name></author><author><name sortKey="Murphy, Brian R" sort="Murphy, Brian R" uniqKey="Murphy B" first="Brian R." last="Murphy">Brian R. 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Steinhoff</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>From the Department of International Health (Center for Immunization Research), School of Hygiene and Public Health, and Departments of Pediatrics and Medicine, School of Medicine, Johns Hopkins University, Baltimore, and Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Reprints and correspondence: Dr. Mark C. Steinhoff, Johns Hopkins University Center for Immunization Research, 624 N. Broadway, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Halsey, Neal A" sort="Halsey, Neal A" uniqKey="Halsey N" first="Neal A." last="Halsey">Neal A. Halsey</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>From the Department of International Health (Center for Immunization Research), School of Hygiene and Public Health, and Departments of Pediatrics and Medicine, School of Medicine, Johns Hopkins University, Baltimore, and Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Wilson, Modena H" sort="Wilson, Modena H" uniqKey="Wilson M" first="Modena H." last="Wilson">Modena H. Wilson</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>From the Department of International Health (Center for Immunization Research), School of Hygiene and Public Health, and Departments of Pediatrics and Medicine, School of Medicine, Johns Hopkins University, Baltimore, and Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Burns, Barbara A" sort="Burns, Barbara A" uniqKey="Burns B" first="Barbara A." last="Burns">Barbara A. Burns</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>From the Department of International Health (Center for Immunization Research), School of Hygiene and Public Health, and Departments of Pediatrics and Medicine, School of Medicine, Johns Hopkins University, Baltimore, and Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Samorodin, Roberta K" sort="Samorodin, Roberta K" uniqKey="Samorodin R" first="Roberta K." last="Samorodin">Roberta K. Samorodin</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>From the Department of International Health (Center for Immunization Research), School of Hygiene and Public Health, and Departments of Pediatrics and Medicine, School of Medicine, Johns Hopkins University, Baltimore, and Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Fries, Louis F" sort="Fries, Louis F" uniqKey="Fries L" first="Louis F." last="Fries">Louis F. Fries</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>From the Department of International Health (Center for Immunization Research), School of Hygiene and Public Health, and Departments of Pediatrics and Medicine, School of Medicine, Johns Hopkins University, Baltimore, and Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Murphy, Brian R" sort="Murphy, Brian R" uniqKey="Murphy B" first="Brian R." last="Murphy">Brian R. Murphy</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>From the Department of International Health (Center for Immunization Research), School of Hygiene and Public Health, and Departments of Pediatrics and Medicine, School of Medicine, Johns Hopkins University, Baltimore, and Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Clements, Mary Lou" sort="Clements, Mary Lou" uniqKey="Clements M" first="Mary Lou" last="Clements">Mary Lou Clements</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>From the Department of International Health (Center for Immunization Research), School of Hygiene and Public Health, and Departments of Pediatrics and Medicine, School of Medicine, Johns Hopkins University, Baltimore, and Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Infectious Diseases</title><title level="j" type="abbrev">J Infect Dis.</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><publisher>The University of Chicago Press</publisher><date when="1990-08">1990</date><biblScope unit="vol">162</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="394">394</biblScope><biblScope unit="page" to="401">401</biblScope></imprint><idno type="ISSN">0022-1899</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-1899</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Randomized, placebo-controlled studies with 103–10' 50% tissue-culture infectious dose (TCID50) of avian-human (ah) and cold-adapted (ca) influenza A/Bethesda/85 (H3N2) reassortant viruses were completed in 106 seronegative young children 6–48 months of age. Although the reassortants differed in six of eight RNA segments, they exhibited similar properties in level of attenuation, infectivity, immunogenicity, and efficacy. The 50% human infectious dose was 104.6 TCID50 for ah and 104.4 for ca vaccines. Both reassortants were satisfactorily attenuated with restricted replication and were no more reactogenic than placebo. The mean peak titer of virus shed was 101.5 (ah) to 102.0 (ca) TCID50/ml, and each of 37 isolates tested retained their characteristic vaccine phenotypes. Infection with ah or ca virus conferred immunity to experimental challenge with homologous virus. These findings indicate that both ah and ca influenza A/Bethesda/85 (H3N2) reassortants should be suitable vaccine candidates for use in healthy infants and young children.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Maryland</li></region></list><tree><country name="États-Unis"><region name="Maryland"><name sortKey="Steinhoff, Mark C" sort="Steinhoff, Mark C" uniqKey="Steinhoff M" first="Mark C." last="Steinhoff">Mark C. Steinhoff</name></region><name sortKey="Burns, Barbara A" sort="Burns, Barbara A" uniqKey="Burns B" first="Barbara A." last="Burns">Barbara A. Burns</name><name sortKey="Clements, Mary Lou" sort="Clements, Mary Lou" uniqKey="Clements M" first="Mary Lou" last="Clements">Mary Lou Clements</name><name sortKey="Fries, Louis F" sort="Fries, Louis F" uniqKey="Fries L" first="Louis F." last="Fries">Louis F. Fries</name><name sortKey="Halsey, Neal A" sort="Halsey, Neal A" uniqKey="Halsey N" first="Neal A." last="Halsey">Neal A. Halsey</name><name sortKey="Murphy, Brian R" sort="Murphy, Brian R" uniqKey="Murphy B" first="Brian R." last="Murphy">Brian R. Murphy</name><name sortKey="Samorodin, Roberta K" sort="Samorodin, Roberta K" uniqKey="Samorodin R" first="Roberta K." last="Samorodin">Roberta K. Samorodin</name><name sortKey="Steinhoff, Mark C" sort="Steinhoff, Mark C" uniqKey="Steinhoff M" first="Mark C." last="Steinhoff">Mark C. Steinhoff</name><name sortKey="Wilson, Modena H" sort="Wilson, Modena H" uniqKey="Wilson M" first="Modena H." last="Wilson">Modena H. Wilson</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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